Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration. Small noncoding RNA interactome capture reveals pervasive, carbon source-dependent tRNA engagement of yeast glycolytic enzymes. Publishing research using ab6160? Please let us know so that we can cite the reference in this datasheet.Īb6160 has been referenced in 500 publications. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.Īcetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some glutamate residues at the C-terminus are polyglutamylated. Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
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